Research Interests

I am specialized in mathematical modelling and computational methods, with a special interest in the biophysics underlying heart rhythm disorders.
I am currently doing research in numerical and theoretical biomedical physics with a focus on nonlinear dynamics, cardiac arrhythmias, and self-termination. The main goal of my project called SASQUATCH (Searching for Arrhythmia Solutions by Quantifying and Unraveling Atrial Transient Chaos) is to find underlying ionic triggers that help in the process of self-termination of dangerous heart rhythm disorders.

Curriculum Vitae

Collaborators

• H. Hupkes, Leiden University, the Netherlands
• M. Chirilus-Bruckner, Leiden University, the Netherlands
• D.A. Pijnappels, , Leiden University Medical Center, the Netherlands
• A.V. Panfilov, Ghent University, Belgium
• U. Parlitz, Max Planck Institute for Dynamics and Self-Organization, Göttingen

Publications and related works

• J. Kamphuis, D. Kabus, H. Hupkes, T. De Coster
  Microscopic Variability Alters Macroscopic Rotation Speed in Stochastic Spiral Waves
  arXiv pre-print (2026): https://doi.org/10.48550/arXiv.2511.21710
  

• T. De Coster, A.A.F. de Vries, D.A. Pijnappels, A.V. Panfilov
  Spirals and other excitation patterns in the heart
  Springer Nature book chapter (2026): https://doi.org/10.1007/978-3-032-08753-9_43
  

• D. Kabus, H. Dierckx, T. De Coster
  Pigreads: The Python-integrated GPU-enabled reaction-diffusion solver using OpenCL for cardiac electrophysiology and other applications
  Computer Physics Communications (2026): https://doi.org/10.1016/j.cpc.2026.110088
  

• S. Deng, N. Harlaar, J. Zhang, S.O. Dekker, N.N. Kudryashova, H. Zhou, C.I. Bart, T. Jin, G. Derevyanko, A.V. Panfilov, R.H. Poelma, A.A.F. de Vries, G.Q. Zhang, D.A. Pijnappels, T. De Coster
  Smart optogenetics for real-time automated control of cardiac electrical activity
  Advanced Science (2026): https://doi.org/10.1002/advs.202522759
  

• A.S. Teplenin, N.N. Kudryashova, R. Majumder, A.A.F. de Vries, A.V. Panfilov, D.A. Pijnappels, T. De Coster
  Atypical collective oscillatory activity in cardiac tissue uncovered by optogenetics
  eLife (2026): https://doi.org/10.7554/eLife.107072
  

• T. De Coster
  (Cardiac) complexity needs interaction
  Scientific Reports (2025): https://doi.org/10.1038/s41598-025-09349-5
  

• T. De Coster, A. Nobacht, T. Oostendorp, A.A.F. de Vries, R. Coronel, D.A. Pijnappels
  Monitoring and modulating cardiac bioelectricity: from Einthoven to End-user
  Europace (2024): https://doi.org/10.1093/europace/euae300
  

• S. Deng, B.L. den Ouden, T. De Coster, C.I. Bart, W.H. Bax, R.H. Poelma, A.A.F. de Vries, G.Q. Zhang, V. Portero, D.A. Pijnappels
  An Untethered Heart Rhythm Monitoring System with Automated AI-Based Arrhythmia Detection for Closed-Loop Experimental Application
  Advanced Sensor Research (2024): https://doi.org/10.1002/adsr.202400057
  

• T. De Coster, A.S. Teplenin, I. Feola, C.I. Bart, A.A. Ramkisoensing, B.L. den Ouden, D.L. Ypey, S.A. Trines, A.V. Panfilov, K. Zeppenfeld, A.A.F. de Vries, D.A. Pijnappels
  ‘Trapped re-entry’as source of acute focal atrial arrhythmias
  Cardiovascular Research Featured (2024): https://doi.org/10.1093/cvr/cvad179
  

• D. Kabus, T. De Coster, A.A.F. de Vries, D.A. Pijnappels, H. Dierckx
  Fast creation of data-driven low-order predictive cardiac tissue excitation models from recorded activation patterns
  Computers in Biology and Medicine (2024): https://doi.org/10.1016/j.compbiomed.2024.107949
  

• T. De Coster, B. Ordog, S.O. Dekker, C.I. Bart, J. Zhang, G.J.J. Boink, W.H. Bax, S. Deng, B.L. den Ouden, A.A.F. de Vries, D.A. Pijnappels
  Opto-electronic feedback control of membrane potential for real-time (re)shaping of action potentials
  Cell Reports Methods (2023): https://doi.org/10.1016/j.crmeth.2023.100671
  

• T. De Coster
  A shock-free approach for ambulatory cardioversion in atrial fibrillation
  American Journal of Physiology-Heart and Circulatory Physiology (2021): https://doi.org/10.1152/ajpheart.00847.2020
  

• V. Biasci, L. Sacconi, E.N. Cytrynbaum, D.A. Pijnappels, T. De Coster, A. Shrier, L. Glass, G. Bub
  Universal mechanisms for self-termination of rapid cardiac rhythm
  Chaos: An Interdisciplinary Journal of Nonlinear Science Featured (2020): https://doi.org/10.1063/5.0033813
  

• T. De Coster, R. Majumder, N. Kudryashova, A.O. Verkerk, I.V. Kazbanov, B. Ordog, N. Harlaar, R. Wilders, A.A.F. de Vries, D.L. Ypey, A.V. Panfilov, D.A. Pijnappels
  Self-restoration of cardiac excitation rhythm by anti-arrhythmic ion channel gating
  eLife (2020): https://doi.org/10.7554/eLife.55921
  

• T. De Coster, P. Claus, G. Seemann, R. Willems, K.R. Sipido, A.V. Panfilov
  Myocyte remodelling due to fibro-fatty infiltrations influences arrhythmogenicity
  Frontiers in Physiology (2018): https://doi.org/10.3389/fphys.2018.01381
  

• T. De Coster, P. Claus, I.V. Kazbanov, P. Haemers, R. Willems, K.R. Sipido, A.V. Panfilov
  Arrhythmogenicity of fibro-fatty infiltrations
  Scientific Reports (2018): https://doi.org/10.1038/s41598-018-20450-w